José R. Rodríguez-Medina has been an independent investigator in the field of molecular biology of yeast for the past 27 years while serving as a member of the Department of Biochemistry at the University of Puerto Rico Medical Sciences Campus (UPR-MSC) in San Juan, P.R. He currently serves as Professor and Chair of the Department of Biochemistry and as Associate Director of Research, Compliance and Development for the UPR Medical Sciences Campus. He is also Program Director of the NIGMS Puerto Rico IDeA Networks for Biomedical Research Excellence (PR-INBRE) and supervises several instrumentation cores for the NIMHD RCMI Program and the Puerto Rico Clinical and Translational Research Consortium (PRCTRC) at UPR-MSC. His research has been focused on topics related to myosin type II and associated cell wall phenotypes of myosin II-deficient (myo1delta) yeast strains, gene expression profiling of these strains, and the mechanism of stress signaling, particularly through the PKC1 pathway, in the response to heat shock and cell wall stress. He has supervised 11 Ph.D. student dissertations during his 27-year career.


  • Nelson Martínez-Matías, Nataliya Chorna, Sahily González–Crespo, Lilliam Villanueva, Ingrid Montes–Rodríguez, et al. “Towards the discovery of biological functions associated with the mechanosensor Mtl1p of Saccharomyces cerevisiae via integrative multi-OMICs analysis.” Scientific Reports, Article DOI: 10.1038/s41598-021-86671-8. Sci Rep. 2021 Apr 1;11(1):7411. doi: 10.1038/s41598-021-86671-8. PMID: 33795741.
  • Vladimir Vélez-Segarra, Sahily González-Crespo, Ednalise Santiago-Cartagena, Luis E. Vázquez-Quiñones, Nelson Martínez-Matías, et al. “Protein Interactions of the Mechanosensory Proteins Wsc2 and Wsc3 for Stress Resistance in Saccharomyces cerevisiae.” G3 (Bethesda). 2020 Sep 2;10(9):3121-3135. doi: 10.1534/g3.120.401468. PMID: 32641451.
  • Ednalise Santiago-Cartagena, Sahily González, Vladimir Velez, Nelson Martínez, Jamie Snider, et al. “Identification and functional testing of novel interacting protein partners for the stress sensors Wsc1p and Mid2p of Saccharomyces cerevisiae.” G3 (Bethesda) 2019 Apr 9;9(4):1085-1102. doi: 10.1534/g3.118.200985. PMID: 30733383