Josué Pérez-Santiago, Ph.D.

Assistant Professor of Computational Biology and Bioinformatics, Division of Cancer Biology, University of Puerto Rico Comprehensive Cancer Center, San Juan, PR.


Complete list of publications:

Dr. Josué Pérez-Santiago double majored in Computer Sciences and Mathematics at the University Puerto Rico, Rio Piedras Campus and later completed his Ph.D. in Bioinformatics & Systems Biology at the University of California San Diego (UCSD), where he studied the gut microbiome during acute and early HIV infection and its association with disease progression and antiretroviral treatment. In his postdoctoral training, Dr. Josué transitioned to neuroAIDS at the HIV Neurobehavioral Research Center at UCSD, where he evaluated the association between cell-free mitochondrial DNA and neuroinflammation, the relationship between the gut microbiome and emotional distress during HIV infection, and mitochondrial genetic defects associated with neurodegeneration, HIV-associated neurocognitive disorders, and methamphetamine use. Currently, he is an Associate Investigator of Bioinformatics and Computational Biology at the University of Puerto Rico Comprehensive Cancer Center and an Assistant Professor of the University of Puerto Rico Medical Sciences Campus, School of Dental Medicine. Dr. Pérez-Santiago’s work focuses on the identification of host-microbial targets within the human microbiome for cancer prevention, early identification, diagnosis, prognosis, and personalized treatments during chronic viral infections such as HPV/HIV, as well as its role in aging-related conditions and co-morbidities. Current research grants include: (1) Transcriptional Effects and Non-transcriptional Effects of Estrogen in the Pathogenesis of Inflammatory Breast Cancer (NCI, grant number 1R21CA253609-01), (2) The Oral Microbiome and its Association with Chronic Inflammation and Cancer Risk in HIV+ Adults (RCMI, grant number U54 MD007600), (3) Cross Sectional Association of the Oral Microbiota and the Inflammasome with Oral HPV among HIV+ Adults (R21, grant number 1R21CA264606-01), (4) The Impact of Short Chain Fatty Acids Treatment in Oral and Breast Cancers (Título 5 RCM – Department of Education, PO31S200104) , and (5) Multi-Omics Predictors of Oral HPV Outcomes among PLWH (NIGMS, grant number 1P20GM148324-01).

(Updated Oct 18, 2023)